Early fixation of an optimal genetic code.

By Stephen J. Freeland, Rob Knight, L. Landweber, L. D. Hurst. 2000

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Citations in the corpus

Collective evolution and the genetic code. (2006, background): “A major advance was provided by computer simulation studies[9, 10, 11, 12, 13, 14] of the relatedness ordering of the amino acids over the codon table, which showed that the code is indeed relationally ordered, and moreover is optimized to near the maximum extent possible.”
A model of substitution trajectories in sequence space and long-term protein evolution. (2015, background): “This may not be entirely the case, for example amino acids in the mutational neighborhood of each other are more likely to be available (Freeland et al. 2000).”
The genetic code is nearly optimal for allowing additional information within protein-coding sequences. (2007, background): “This feature has been attributed to an adaptive selection of a code, so that errors that misread a codon by one letter would result in minimal effects on the translated protein (Freeland and Hurst 1998; Freeland et al. 2000; Gilis et al. 2001; Wagner 2005b).”
Origin and evolution of the genetic code: the universal enigma (2008, background): “However, several detailed analyses have suggested that coevolution alone cannot explain the observed level of robustness of the standard code, so that additional evolution under selection for error minimization would be necessary to arrive to the standard code (82, 85, 112).”
Understanding the adaptation of Halobacterium species NRC-1 to its extreme environment through computational analysis of its genome sequence. (2001, background): “The majority (69 of 91) of IS elements were also localized to the minichromosomes, which, along with the other genomic repeats, accounts for the dynamic nature of the genome (Charlebois and Doolittle 1989; Ng et al. 1991; Hackett et al. 1994).”
The evolution of the genome (2005, background): “All things considered, it is the best of all possible codes (Freeland et al 2000, Itzkovitz & Alon 2007).”
Rewiring the keyboard: evolvability of the genetic code (2001, background): “Although mitochondrial variant codes are close to this optimum, they all seem slightly worse than the canonical cod”