Evolution of the lectin–complement pathway and its role in innate immunity

By T. Fujita. Nature reviews. Immunology, 2002

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The lectin‐complement pathway – its role in innate immunity and evolution (2004, methodology): “This figure was reprinted by permission from Nature Reviews Immunology (4) [copyright (2002) Macmillan Magazines Ltd] with modification.”
Recent advances in the innate immunity of invertebrate animals. (2005, background): “…peptide production (Lemaitre et al., 1996; Imuler and Hoffmann, 2000; Krutzik et al., 2001; Underkill and Orinsky, 2002), hemolymph coagulation (Iwanaga et al., 1978), melanin formation (Sugumaran, 2002), and lectin-mediated complement activation (Fujita, 2002) are prominent immune responses.”
The complement system: an unexpected role in synaptic pruning during development and disease. (2012, background): “The antibodyindependent lectin pathway is triggered by the binding of mannose binding lectin (MBL) and a group of related proteins that recognize terminal sugar moieties expressed on polysaccharides or glycoproteins on cell membranes (Fujita 2002, Degn et al. 2007).”
Recent advances on the complement system of teleost fish. (2006, background): “In the lectin pathway, interaction of sugars with MBL or ficolins lead to the activation of MBL-associated serine proteases (MASPs) which in turn cleave C4 and C2 [68].”