The Effect of Metformin and Intensive Lifestyle Intervention on the Metabolic Syndrome: The Diabetes Prevention Program Randomized Trial
By T. Orchard, M. Temprosa, R. Goldberg, S. Haffner, R. Ratner, Santica M. Marcovina, S. Fowler. Annals of Internal Medicine, 2005
998 citations recorded by the source corpus.
Subfields: Endocrinology, Diabetes and Metabolism, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2149bc51fe8d1d966c4657a6a6256887e15f75fa
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Endocrinology, Diabetes and Metabolism
In Molecular Biology
Citations in the corpus
- Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training (2013, positive): “In the Diabetes Prevention Program, lifestyle intervention resulted in 3-year cumulative diabetes incidence of 51%, 45%, and 34% in placebo, metformin, and lifestyle groups associated with a 41% reduction in the lifestyle group and a 17% reduction in the metformin group (478).”
- The metabolic syndrome. (2008, background): “They evaluated the incidence of new MetS cases and resolution of existing MetS cases compared with placebo treatment in participants (n 3234) of the DPP trial.”
- A Comprehensive Review on Metabolic Syndrome (2014, result): “Incidence of the MetS was also reduced by 17% in the metformin-treated group of the DPP, which was driven primarily by improvements inWCand fasting glucose, whereas, intensive therapeutic lifestyle changes reduced this risk by 58% compared to placebo [210].”