Clinical importance of the cytochromes P450.
By D. Nebert, David W. Russell. The Lancet, 2002
1,419 citations recorded by the source corpus.
Subfields: Clinical Biochemistry, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/20aaeabedd9dc0a949850860e904d128405234f8
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In Clinical Biochemistry
In Oncology
In Pharmacology
Citations in the corpus
- Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. (2004, background): “The mammalian cytochrome P450 (CYP) superfamily encodes enzymes involved in: the metabolism of pharmaceuticals, foreign chemicals and pollutants; arachidonic acid metabolism and eicosanoid biosynthesis; cholesterol, sterol and bile acid biosynthesis; steroid synthesis and catabolism; vitamin D3 synt”
- Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction (2006, background): “Some examples of drugs metabolised by CYP3A are terfenadine, the benzodiazepines midazolam and triazolam, quinidine, lidocaine, carbamazepine, nifedipine, tacrolimus, dapsone, erythromycin and dextromethorphan [41,181].”
- Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “…genes, which are grouped according to their sequence similarity into 18 families and 44 subfamilies (http://drnelson.uthsc.edu/ human.P450.table.html), have specific endogenous functions including the biosynthesis of steroid hormones, prostaglandins, bile acids, and others (Nebert & Russell, 2002).”
- Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “CYPs represent the most important phase I drug-metabolizing enzymes that oxidize a number of endogenous substances and xenobiotics, including more than 90% of all medications into more hydrophilic compounds (Nebert and Russell, 2002).”
- ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “It belongs to the CYP superfamily of integral membrane proteins that catalyze the oxidation of numerous organic substrates, accompanied by the reduction of molecular oxygen [147].”