Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

By David R. Nelson, D. Zeldin, S. Hoffman, L. Maltais, H. Wain, D. Nebert. Pharmacogenetics (London), 2004

1,054 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/96f338f8faa951cbfca23ee5c975621bbde4c304

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Shufeng Zhou
2. David R. Nelson

In Pharmacology

1. Shufeng Zhou
2. M. Schwab
3. Jun-Ping Liu
4. B. Chowbay
5. Ulrich M. Zanger

Citations in the corpus

• The Cytochrome P450 Homepage (2009, background): “Today, a single plant genome may have over 300 CYP genes, and if you include pseudogenes, over 400 CYPs.”
• Polymorphism of human cytochrome P450 enzymes and its clinical impact (2009, background): “In mice, there are at least nine different mouse Cyp2d genes identified, including Cyp2d9-2d13 and 2d22 (Nelson et al., 2004).”
• Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation. (2013, background): “2 that contains genes and pseudogenes of the CYP2A, 2B, 2F, 2G, 2S and 2T subfamilies (Hoffman et al., 2001; Nelson et al., 2004 Only CYP2A6 and CYP2A13 are functional whereas CYP2A7 apparently encodes a nonfunctional gene, although CYP2A7 cDNA generates an immunoreactive protein unable to…”