Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date

By M. Döbrössy, Elodie Drapeau, C. Aurousseau, M. Le Moal, P. Piazza, D. Abrous. 2003

274 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Developmental Neuroscience

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. Gerd Kempermann
4. E. Gould
5. D. Abrous
6. B. Leuner
7. M. Koehl
8. M. Le Moal

In Cognitive Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. E. Gould
4. D. Abrous
5. Gerd Kempermann
6. B. Leuner
7. M. Le Moal
8. P. Piazza

In Developmental Neuroscience

1. Fred H. Gage
2. Hongjun Song
3. E. Gould
4. B. Leuner
5. D. Abrous
6. Gerd Kempermann
7. Guo-li Ming
8. M. Le Moal

Citations in the corpus

• Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons (2007, background): “Third, spatial learning has been shown to increase both the survival of newborn neurons [19] and cell proliferation [16,20].”
• Nuclear factor of activated T cells (NFATc4) is required for BDNF-dependent survival of adult-born neurons and spatial memory formation in the hippocampus (2012, background): “Indeed it has been demonstrated that the newborn neurons are incorporated into DG circuits supporting water maze memory (1, 55) and that spatial learning influences the survival of newborn neurons (56).”
• Structural Plasticity and Hippocampal Function (2010, background): “…learning in the watermaze task has been linked to no effect or to a decrease in the number of newborn neurons in the dentate gyrus (Ambrogini et al. 2004, Döbrössy et al. 2003, Dupret et al. 2007, Ehninger & Kempermann 2006, Epp et al. 2007, Mohapel et al. 2006, Van der Borght et al. 2005b).”
• The Timing of Differentiation of Adult Hippocampal Neurons Is Crucial for Spatial Memory (2008, unknown): “campus and cognitive processes [9, 29–33].”
• Mechanisms and functional implications of adult neurogenesis. (2008, unknown): “…phase of training in the Morris water maze, during which rapid improvement of performance is achieved, has no effect on cell proliferation, whereas the late asymptotic phase increases cell proliferation and decreases the survival of new cells produced in the early phase (Dobrossy et al., 2003).”
• Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats (2007, background): “Learning decreases the number of BrdU-IR cells produced during the early phase of spatial learning in aged rats with preserved spatial memory (second experiment) We have shown in young adult rats that the late phase of learning, characterized by a lack of additional improvement of the performances, ”
• Adult neurogenesis: from precursors to network and physiology. (2005, background): “However, adult-born neurons that have been recruited by learning survive for several weeks (121, 309) and thus outlive the time required for cortical transfer.”
• Learning Enhances the Survival of New Neurons beyond the Time when the Hippocampus Is Required for Memory (2004, background): “F, 4).”
• Neurogenesis in the Adult Hippocampus. (2015, background): “Exposure to the complexity of an enriched environment or, at least in some studies, to learning stimuli of hippocampus-dependent learning tasks increase survival at this stage (Gould et al. 1999; Dobrossy et al. 2003).”
• Temporal Discontiguity Is neither Necessary nor Sufficient for Learning-Induced Effects on Adult Neurogenesis (2006, background): “…to various types of learning and memory (Kempermann et al., 2004; Becker, 2005; Leuner et al., 2006), and learning certain tasks can alter the number of new neurons (Gould et al., 1999; Ambrogini et al., 2000; Dobrossy et al., 2003; Leuner et al., 2004; Hairston et al., 2005; Olariu et al., 2005).”