Brain inflammation and adult neurogenesis: the dual role of microglia.

By Christine T. Ekdahl, Z. Kokaia, O. Lindvall. 2009

814 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Pediatrics, Perinatology and Child Health

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Citations in the corpus

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Under inflammatory conditions, reactivated microglia can have both beneficial and detrimental effects on different aspects of adult neurogenesis, depending on the balance between secreted molecules with pro-and anti-inflammatory action (reviewed by Ekdahl et al., 2009).”
Microglia: biology and pathology (2009, background): “There is clear experimental evidence which shows that activated microglia can be beneficial [49].”
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders (2010, background): “and contribute to an environment that supports neuronal viability and regeneration, and myelin sheath formatio”
Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, neutral): “This niche also includes microglia, the primary immune cell type present in the brain (Walton et al., 2006; Ekdahl et al., 2009; Thored et al., 2009).”
The potential of neural stem cells to repair stroke-induced brain damage (2009, background): “Ischemic brain injury induces a massive inXammatory reaction that potentially inhibits neurogenesis in adult brain [ 24 , 92].”
Immune modulation of learning, memory, neural plasticity and neurogenesis. (2011, positive): “Although initially microglia were shown to be involved in neurogenesis suppression, it is now clear that under quiescent conditions they play a role in supporting neurogenesis (Ekdahl et al., 2009; Hanisch and Kettenmann, 2007; Ziv and Schwartz, 2008).”
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders (2010, neutral): “For example, microglial activation, which occurs in response to increased oxidative stress, can have either bene-ﬁcial or detrimental effects on neurons and neural progenitor cells depending upon the type and amounts of cytokines and growth factors secreted by the microglia (168).”
Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis (2010, background): “Previous reports had indicated either beneficial or detrimental effects of activated microglia on SGZ neurogenesis, depending on the particular paradigm of activation studied (Ekdahl et al., 2009).”
Microglia in the TBI Brain: The Good, The Bad, And The Dysregulated (2015, background): “…these, and other protective factors released by microglia (e.g. protease serine 2; Nikolakopoulou et al., 2013), can increase neural precursor cell proliferation, neuroblast migration and functional integration of new born neurons into the SGZ of the adult hippocampus (Ekdahl et al., 2009).”
The biphasic function of microglia in ischemic stroke (2017, neutral): “Under pathological conditions including ischemic stroke, microglia exhibit biphasic functions in neurogenesis (Ekdahl et al., 2009).”
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. (2019, background): “Ekdahl and colleagues (52) reported, in 2009, an increased number of activated microglial cells up to 16 wk after 2 h of MCAO in rats.”