From the regulation of peptidoglycan synthesis to bacterial growth and morphology

By Athanasios Typas, M. Banzhaf, Carol A. Gross, W. Vollmer. Nature Reviews Microbiology, 2011

1,222 citations recorded by the source corpus.

How bacteria grow and divide while retaining a defined shape is a fundamental question in microbiology, but technological advances are now driving a new understanding of how the shape-maintaining bacterial peptidoglycan sacculus grows. In this Review, we highlight the relationship between peptidoglycan synthesis complexes and cytoskeletal elements, as well as recent evidence that peptidoglycan growth is regulated from outside the sacculus in Gram-negative bacteria. We also discuss how growth of the sacculus is sensitive to mechanical force and nutritional status, and describe the roles of peptidoglycan hydrolases in generating cell shape and of D-amino acids in sacculus remodelling.

Subfields: Ecology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/201633cb06a1efb8008f3fbd6281b2ee0716756d

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Citations in the corpus

Beta-lactam antibiotics induce a lethal malfunctioning of the bacterial cell wall synthesis machinery (2014, background): “Proper PG biogenesis by these systems in E. coli is also thought to require the aPBPs, PBP1a and PBP1b, to promote glycan chain polymerization and crosslinking (Typas et al., 2012) (Figures 1B–1D).”
Relating the metatranscriptome and metagenome of the human gut (2014, background): “To perform those roles, peptidoglycan biosynthesis must be carefully regulated to coordinate with cellular growth (29).”