Mechanism of Action

By Amit Jain. Definitions, 2020

774 citations recorded by the source corpus.

AML is one of the most common acute leukemias in adults. While many patients will achieve remission, up to 50% will relapse within one year, and long-term survival averages at six months.2,3 Onureg is used for the treatment of adult patients with AML who achieved first complete remission (CR) or CR with incomplete blood count recovery (CRi) following induction therapy with or without consolidation treatment, and who are not eligible for hematopoietic stem cell transplantation (HSCT).1 Onureg® (azacitidine tablets) Mechanism of Action

Subfields: Cognitive Neuroscience, Computational Theory and Mathematics, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/1f70d7e256f90cb4b7f5899dac15bc41bdddf10d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cognitive Neuroscience

1. U. Rudolph
2. V. Gallego
3. J. Asturiano

In Computational Theory and Mathematics

1. V. Gallego
2. J. Asturiano

In Experimental and Cognitive Psychology

1. V. Gallego
2. J. Asturiano

Citations in the corpus

• Application of enzymes for textile fibres processing (2008, neutral): “…catalyse the post-translational modification of proteins mainly by protein to protein cross-linking, but also through the covalent conjugation of polyamines, lipid esterification or the deamidation of glutamine residues (Folk & Cole 1966; Folk et al. 1968; Folk 1969, 1980; Lorand & Conrad 1984).”
• Cellular Mechanotransduction: From Tension to Function (2018, background): “…stabilizers Phallotoxin (Phalloidin) Natural compound (Amanita phalloides) F-actin binding, ATP hydrolisis and depolymerization inhibition Estes et al., 1981 Jasplakinolide Natural compound (Jaspis johnstoni) F-actin nucleation and polymerization enhancement Bubb et al., 1994, 2000;…”
• A new benzodiazepine pharmacology. (2002, background): “Among 1-, 2-, and 3-point-mutated mice only the 1(H101R) mutants were resistant to the depression of motor activity by diazepam and zolpidem (Rudolph et al., 1999; Crestani et al., 2000a; Löw et al., 2000).”
• Glycosylation with activated sugars using glycosyltransferases and transglycosidases (2006, background): “Isomaltotriose (a-D-glucopyranosyl-1,6-a-D-glucopyranosyl-1,6-D-glucopyranose), panose (a-D-glucopyranosyl-1,6-a-D-glucopyranosyl -1,4- D-glucop - yranose) and maltotriose (Binder et al. 1983; Kitaoka & Robyt 1999) are also substrates of GTF.”
• Fish sperm motility assessment as a tool for aquaculture research: a historical approach (2019, background): “…lota In vitro 25 mg/L Lahnsteiner et al. (2004) Mercury Oncorhynchus mykiss In vitro 10 mg/L (4h) Dietrich et al. (2010) Perca fluviatilis In vitro 62 µM Hatef et al. (2011) Perca fluviatilis In vitro 31 µM (3h) Hatef et al. (2011) Clarias gariepinus In vitro 0.001 mg/L Rurangwa et al. (1998)…”