LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA.

By B. Vester, J. Wengel. Biochemistry, 2004

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Critical review on biofilm methods (2017, background): “Chemically speaking, these mimics differ from DNA or RNA by modifications at the level of the back-bone, both in the phosphate group and in the pentose sugar (Nielsen et al., 1991; Vester & Wengel, 2004).”
Targeting MicroRNAs in Cancer: Rationale, Strategies and Challenges (2010, neutral): “By locking the molecule with the methylene bridge, LNA oligonucleotides display unprecedented hybridization affinity towards complementary single-stranded RNA and complementary single-stranded or double-stranded DN”
Plant microRNAs: new players in functional genomics (2013, neutral): “Recently, the development of locked nucleic acid (LNA) oligonucleotide probes, which have a high degree of complementary with the miRNA, has paved the way for efficient detection of animal and plant miRNAs when compared with conventional RNA probes (Valoczi et al. 2004; Vester and Wengel 2004).”
Silencing of microRNA families by seed-targeting tiny LNAs (2011, background): “In addition, structural studies have shown that the fixed N -type conformation of the LNA nucleoside preorganizes LNA oligonucleotides in a high-affinity conformation for binding complementary RNA sequences, thereby adopting an A-form helix geometry typical for RNA-RNA duplexe”