The Polo kinase Plk4 functions in centriole duplication

By Robert Habedanck, York Stierhof, C. Wilkinson, Erich A. Nigg. Nature Cell Biology, 2005

889 citations recorded by the source corpus.

Subfields: Cell Biology, Oncology, Plant Science

View Paper: https://www.semanticscholar.org/paper/4ff0a12963aca8b74eaa05795feba2467ccb4533

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Jens Lüders
2. K. Strebhardt
3. J. Raff
4. J. Kleylein-Sohn
5. Hidde L. Ploegh
6. Erich A. Nigg
7. York Stierhof
8. Jonathan S. Weissman

In Oncology

1. K. Strebhardt
2. Erich A. Nigg
3. Jens Lüders

In Plant Science

1. Lei S. Qi

Citations in the corpus

• Flies without centrioles. (2006, background): “The polo-like kinase Plk-4/Sak is essential for centriole replication (Bettencourt-Dias et al., 2005; Habedanck et al., 2005), and Drosophila sak hypomorphic mutant third-instar larval brains appear to lack centrioles in 20% of their cells, yet they develop into adults at rates that are only slightl”
• Centrioles, centrosomes, and cilia in health and disease. (2009, background): “Remarkably, excess Plk4 kinase activity can lead to the simultaneous formation of multiple centrioles around a single parent, suggesting that Plk4 overexpression creates additional sites on “duplication-competent” parental centrioles (Habedanck et al., 2005; Kleylein-Sohn et al., 2007).”
• Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation (2014, background): “PLK4 controls centrosome duplication, and overexpression of the gene in U2OS cells leads to increased centriole number (Habedanck et al., 2005).”
• The Microtubule Cytoskeleton (2016, background): “CEP152 is required for CDK5RAP2, CNTROB and CENPJ recruitment to centrosomes, and CEP152 may cooperate with CEP192 to recruit the kinase PLK4 (Firat-Karalar et al. 2014; Guernsey et al. 2010; Habedanck et al. 2005; Kaindl 2014; Kim et al. 2013; Kleylein-Sohn et al. 2007; Sonnen et al. 2013).”
• Plk4-induced centriole biogenesis in human cells. (2007, methodology): “However, the centrosome amplification seen in Plk4 cells may be explained by the cell division failures that occur upon depletion of Plk4, possibly as a consequence of abnormal spindle formation (Habedanck et al., 2005).”
• Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy (2010, background): “( Box 2 ) suggesting that PLK2 functions are not essential or that there is some functional redundancy with PLK4, which has been shown to have a crucial role in the duplication of the centriol”