Marrow stromal cells form guiding strands in the injured spinal cord and promote recovery

By C. Hofstetter, E. Schwarz, D. Hess, J. Widenfalk, A. Manira, D. Prockop, L. Olson. Proceedings of the National Academy of Sciences of the United States of America, 2002

1,009 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Genetics

View Paper: https://www.semanticscholar.org/paper/1ee8242352b43f5e58a35ed5f376ac5f1f040c40

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Developmental Neuroscience

1. S. Shi
2. S. Gronthos

In Genetics

1. G. T. Huang
2. S. Shi
3. S. Gronthos
4. I. Sekiya
5. C. Gregory
6. H. Koga
7. Akimoto Nimura
8. A. Yokoyama

Citations in the corpus

• Matrix elasticity directs stem cell lineage specification. (2006, background): “…Sweeney,1 and Dennis E. Discher1,2,3,4,* 1Pennsylvania Muscle Institute 2School of Engineering and Applied Science 3Cell & Molecular Biology Graduate Group 4Physics Graduate Group University of Pennsylvania, Philadelphia, PA 19104, USA *Contact: discher@seas.upenn.edu DOI 10.1016/j.cell.2006.06.044”
• Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle (2007, methodology): “Passage 5 cells were used for implantation (Hofstetter et al. 2002).”
• Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine (2009, background): “In rodent systems, BMMSCs have been shown to differentiate into astrocytes and, in some instances, neurons after transplantation into the mouse brain (Kopen et al., 1999), or to facilitate functional recovery of damaged brain or spinal cord in rats (Chen et al., 2001; Hofstetter et al., 2002).”
• Same or Not the Same? Comparison of Adipose Tissue-Derived Versus Bone Marrow-Derived Mesenchymal Stem and Stromal Cells (2012, positive): “However, it is crucial to confirm that the differentiated progenies of MSCs adopt not only the phenotype of particular specialized cells, but also gain their function and persist for sufficient time in the restored tissue, because some studies have shown that while MSCs may acquire a differentiated ”
• The Regulation of Differentiation in Mesenchymal Stem Cells (2010, neutral): “The clinical relevance of the presumptive nonmesenchymal potency of MSCs is, however, questioned because, for example, MSC-derived neuron-like cells were unable to generate action potentials and, therefore, to function as neurons (Hofstetter et al. , 2002).”
• Mechanisms of mesenchymal stem/stromal cell function (2016, background): “In short, while MSCs were found to exhibit a remarkable degree of efficacy in a variety of disease models, it became increasingly apparent that the cells did not engraft in significant numbers or for durations sufficient to explain the results in terms of tissue replacement [11–15].”