Structural biology of shared cytokine receptors.

By Xinquan Wang, P. Lupardus, S. L. LaPorte, K. Garcia. 2009

410 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. (2016, background): “It consists of IL-7Ra (CD127) and gc (CD132) chains (Fig 1).(76) IL-7 responses are determined by expression of IL-7Ra, which is shared with the TSLP receptor, because gc is ubiquitously expressed on lymphocytes.”
Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1 (2017, background): “The CHR domains included the WSXWS motif in D3 (W304 Q305 P306 W307 S308), and adopted an inter-domain orientation reminiscent of CHR domains in the common gamma ( γ c) family of receptors (Verstraete et al., 2014; Wang et al., 2009).”
Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “Cytokines can also be grouped according to the type of receptor they bind, which comprise six major families: class I cytokine receptors (the largest family), class II cytokine receptors, TNF receptors, tyrosine kinase receptors, and chemokine receptors [5].”
New insights into the regulation of T cells by γc family cytokines (2009, neutral): “The structures of some of the receptors for members of the γ c family are known, providing insight into how different cytokines can each interact with γ c”