A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

By V. Kirkin, T. Lamark, Yu-shin Sou, G. Bjørkøy, Jennifer A. L. Nunn, J. Bruun, E. Shvets, David G. McEwan, T. Clausen, P. Wild and 8 more. Molecules and Cells, 2009

1,187 citations recorded by the source corpus.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1ecb075387b18693946ab0a8be10cfbff569593a

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Citations in the corpus

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport (2010, background): “…Okazaki et al., 2000; Sagiv et al., 2000; Kim et al., 2002; Mansuy et al., 2004; Mohrlüder et al., 2007a,b; Pankiv et al., 2007; Cook et al., 2008; Kirkin et al., 2009; Nowak et al., 2009; Schwarten et al., 2009; Zhang et al., 2009) suggests that similar to Rabs, ATG8 family proteins may function…”
Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway (2012, neutral): “It will be interesting to determine whether other ubiquitin-binding adaptors implicated in autophagy, including NBR1 and optineurin, are also important for this pathway (Kirkin et al., 2009; Wild et al., 2011b).”
Ubiquitination and selective autophagy (2012, background): “NBR1 can directly bind to p62, and together they act as cargo receptors for autophagic degradation of ubiquitinated substrates.(6,7,53)”
Mechanisms of Selective Autophagy (2016, neutral): “Given that many cargo receptors form dimers or multimers and/or contain multiple LIR motifs, avidity-driven interactions with membrane-localized Atg8-family proteins are likely to be a more general property of cargo receptors [30,49,56,84,91 – 94].”
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both (2010, background): “The C-terminal mitochondrial anchoring tails of Bcl-X L (213–233), Bax (EYFP20),(29) and Fis1 (92–152) were fused to the FRB domain, while UbG76V-GFP mitochondria that appear tethered together by polymerized p62, binding between polymerized p62 molecules (and possibly other molecules binding p62, su”
Eaten alive: a history of macroautophagy (2010, background): “Mounting evidence suggests that p62 and NBR1, another apparent autophagy receptor with similar domain”
An Overview of Autophagy: Morphology, Mechanism, and Regulation (2014, background): “NBR1 and OPTN are other receptors that function in targeting ubiquitinated proteins or pathogens to autophagosomes (75, 147).”
Cellular and molecular mechanisms of muscle atrophy (2013, neutral): “…Bentzinger et al., 2008 FoxO1 Muscle-specific transgenic Muscle atrophy Kamei et al., 2004 FoxO1 Muscle-specific KO Slow-to-fast myofiber switch Kitamura et al., 2007 FoxO3 Inducible KO Normal Paik et al., 2007 TGF -myostatin signaling pathway Myostatin Total KO, muscle-specific KO Muscle…”
Autophagy mediates degradation of nuclear lamina (2015, neutral): “GST, GST-LC3A, B, C, and GST-LC3B mutants/truncations were described elsewhere 33 .”