Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

By N. Kosaka, Haruhisa Iguchi, T. Ochiya. Cancer Science, 2010

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Cell-free nucleic acids as biomarkers in cancer patients (2011, methodology): “The application of these techniques has shown conflicting quantitative data on the upregulation of circulating miRNAsfrom the same tumour type in different studie”
Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies (2011, background): “Since the initial description of circulating microRNAs (miRNAs) in 2008 (1–4), more than 200 articles have reported circulating miRNAs as biomarkers for a range of cancer types and other diseases (5, 6).”
Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. (2011, background): “Emerging evidence suggests that, in cancer patients, circulating miRNAs are stable in blood, probably due to their incorporation in exosomes/microvesicles, allowing their use as novel diagnostic markers (12).”
Comparing the MicroRNA Spectrum between Serum and Plasma (2012, background): “These findings raise the possibility of using the levels of specific miRNAs in circulation as biomarkers for different pathological conditions [8–12].”