GPCR Engineering Yields High-Resolution Structural Insights into β2-Adrenergic Receptor Function

By D. Rosenbaum, Vadim Cherezov, M. Hanson, S. Rasmussen, Foon Sun Thian, T. S. Kobilka, Hee-Jung Choi, X. Yao, William I. Weis, Raymond C. Stevens and 1 more. Science, 2007

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GPCR Network: a large-scale collaboration on GPCR structure and function (2012, background): “Additional structure reports include the characterization of the active and inactive states for rhodopsin 36 and opsin 37 , β 2 -AR 38–41 and adenosine A 2A receptor 18,42,43 .”
The Molecular Basis of G Protein–Coupled Receptor Activation (2018, background): “Spectroscopic studies, however, have shown that the presence of a fusion protein in ICL3 can alter conformational equilibria (19).”
Structure-based drug discovery and protein targets in the CNS. (2011, background): “The recent breakthroughs are described in more detail below, but in summary have introduced mutations (Warne et al., 2008), an additional domain (Cherezov et al., 2007) or complexation with antibody (Rosenbaum et al., 2007).”