IL-1 and related cytokines in innate and adaptive immunity in health and disease

By A. Mantovani, C. A. Dinarello, Martina Molgora, C. Garlanda. Immunity, 2019

880 citations recorded by the source corpus.

Forty years after its naming, IL-1 and related cytokines experience a renaissance as central mediators of inflammation and immunity. IL-1 family members, including IL-18, IL-33, IL-36, IL-37, and IL-38, play a key role in the orchestration of the diversity and plasticity of innate and adaptive immune responses. As such, these molecules are involved in homeostasis and in a range of pathologies, ranging from autoimmunity and autoinflammation, to dysmetabolism and cardiovascular disorders, to cancer. Dissection of the complexity and role in immunopathology of the IL-1 family has paved the way to development of trans-disease therapeutic strategies. Therefore, IL-1 serves as a paradigm for immunity and inflammation representing a metanarrative of modern medicine.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1d9443493940cc0ceb46c503fe4dc855d0bd863c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. M. Locati
3. G. Curtale
4. A. Sica
5. P. Allavena
6. F. Martínez
7. S. Gordon
8. C. Garlanda

In Molecular Biology

1. A. Mantovani
2. M. Locati
3. G. Curtale
4. M. Karin

Citations in the corpus

• Diverse Functional Autoantibodies in Patients with COVID-19 (2020, neutral): “IL-18Rβ serves as a component of the heterodimeric IL-18 receptor (which also contains IL-18Rα), which is a proinflammatory cytokine critical for antiviral NK and CD8 + T cell responses 28,29 .”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “Interestingly, IL-1β has been shown to be a major driver of training at the level of myeloid precursors and differentiated monocytes (8, 38).”