Two-component and phosphorelay signal transduction.

By J. Hoch. 2000

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Citations in the corpus

Direct-coupling analysis of residue coevolution captures native contacts across many protein families (2011, neutral): “f iðAÞ 1⁄4 ∑ B PðdirÞ ij ðA;BÞ; f jðBÞ 1⁄4 ∑ A PðdirÞ ij ðA;BÞ: [12]”
Dissecting the Specificity of Protein-Protein Interaction in Bacterial Two-Component Signaling: Orphans and Crosstalks (2011, background): “A prominent example in bacteria is the two-component signaling (TCS) system, which is highly amplified in the bacterial genomes [1].”
Evolutionary resurrection of flagellar motility via rewiring of the nitrogen regulation system (2015, background): “Bacteria respond to diverse 20 environments using a vast range of specialised regulatory pathways, predominantly 21 two-component systems (3), which are the result of adaptive radiations within gene 22”
How antibiotics kill bacteria: from targets to networks (2010, background): “Evidence suggests that some of these non-lytic pathways are regulated by bacterial two-component systems”
Stimulus Perception in Bacterial Signal-Transducing Histidine Kinases (2006, background): “These findings raise the possibility that the extracytoplasmic domains of some sensor proteins classified as periplasmic-sensing HKs are unnecessary for stimulus perception (102).”
Features of protein-protein interactions in two-component signaling deduced from genomic libraries. (2007, background): “In short, the ultimate association between signal and response is achieved through a transient phosphotransfer interaction between the HisKA and RR proteins ( Hoch, 2000; Ninfa et al., 1988; Parkinson, 1993; Stock et al., 1989, 2000).”
Computational modeling of phosphotransfer complexes in two-component signaling. (2010, background): “Extended versions of the TCS signal transduction pathway are the phos-phorelays (Hoch, 2000).”
High-resolution protein complexes from integrating genomic information with molecular simulation (2009, background): “In TCS, a sensor histidine kinase (SK) and a response regulator/transcription factor protein (RR) connect an input signal to an appropriate response by forming a complex to facilitate a transphosphorylation reaction between the two proteins (8, 9).”
Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information (2014, background): “A closely related extension of TCS called the phosphor-elay (3) has evolved to contain an additional intermediate RR, which lacks a DNA-binding domain, and an intermediate phos-photransferase protein (Fig.”
ColR-ColS signalling system and transposition of Tn4652 in the adaptation of Pseudomonas putida (2010, background): “There are different regulatory circuits used by bacteria; from single component systems to multi-component relays and regulatory cascades (Hoch, 2000; Ulrich et al., 2005; West and Stock, 2001), which include various components such as kinases and phosphatases, adenylate and diguanylate cyclases,…”
P2CS: a two-component system resource for prokaryotic signal transduction research (2009, background): “In 4-step phosphorelays, the phosphoaccep-tor domains can be found distributed across 2 to 4 individual proteins [2].”
Inference of direct residue contacts in two-component signaling. (2010, background): “The common signaling cascade utilized by the bacteria is the twocomponent system (Hoch, 2000).”
Domain Architectures of σ54-Dependent Transcriptional Activators (2003, background): “Two-component systems have evolved to allow bacteria to sense and respond to a wide range of stresses and environmental cues (25, 62).”
Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes (2016, background): “An important example is two-component signaling (TCS) (Hoch 2000; Stock et al. 2000; Laub and Goulian 2007; Casino et al. 2010; Szurmant and Hoch 2010; Capra and Laub 2012), which serves as the primary means for bacteria to sense the environment and carry out appropriate responses.”