MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents.

By B. Kaina, M. Christmann, S. Naumann, W. Roos. DNA Repair, 2007

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MGMT promoter methylation in malignant gliomas: ready for personalized medicine? (2010, background): “MGMT is associated with resistance to alkylating agent cancer therapy, and modulation of this enzyme as a treatment target has been under investigation for over 2 decades.(1,2) MGMT rapidly reverses alkylation, including methylation, at the O(6) position of guanine by transferring the alkyl group to”
An engineered protein tag for multiprotein labeling in living cells. (2008, result): “This observation is in agreement with the fact that numerous spontaneous immortalized and virus-transfected cell lines are AGT deficient, whereas the expression level of cell lines that do express AGT has been reported to be around 0.1–1 pmol/mg (Foote and Mitra, 1984; Kaina et al., 2007 ).”
Mechanisms of DNA damage, repair and mutagenesis (2017, background): “A single AGT molecule removes the alkylation adduct in a one step reaction by transferring the alkyl group from the oxygen of the DNA base to the cysteine residue in its catalytic pocket [Kaina et al., 2007].”
SERIES: Genomic instability in cancer Balancing repair and tolerance of DNA damage caused by alkylating agents (2012, background): “The mismatch repair (MMR) pathway recognizes and processes DNA base mismatches to remove misincorporated nucleotides; this includes the O 6 meG:T mispairs that arise by the incorporation of thymine opposite O 6 meG during replication of alkylated DN”