Zinc and Oxidative Stress: Current Mechanisms
By D. Marreiro, Kyria Jayanne Clímaco Cruz, Jennifer Beatriz Silva Morais, J. B. Beserra, J. S. Severo, Ana Raquel Soares de Oliveira. Antioxidants, 2017
598 citations recorded by the source corpus.
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules, contributing to the oxidative damage of cells and tissues. This consequently contributes to the development of several chronic diseases. In particular, zinc is one of the most relevant minerals to human health, because of its antioxidant properties. This review aims to provide updated information about the mechanisms involved in the protective role of zinc against oxidative stress. Zinc acts as a co-factor for important enzymes involved in the proper functioning of the antioxidant defense system. In addition, zinc protects cells against oxidative damage, acts in the stabilization of membranes and inhibits the enzyme nicotinamide adenine dinucleotide phosphate oxidase (NADPH-Oxidase). Zinc also induces the synthesis of metallothioneins, which are proteins effective in reducing hydroxyl radicals and sequestering reactive oxygen species (ROS) produced in stressful situations, such as in type 2 diabetes, obesity and cancer. Literature provides strong evidence for the role of zinc in the protection against oxidative stress in several diseases.
Subfields: Health, Toxicology and Mutagenesis, Nutrition and Dietetics, Plant Science
View Paper: https://www.semanticscholar.org/paper/1ccb9988f3cf673f29e03f4ab9301cbe5fc8e392
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Citations in the corpus
- Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis (2019, background): “The general endogenous antioxidant system consisting of enzymatic antioxidants (SOD, CAT, GPx, and Trx) and nonenzymatic antioxidants (vitamins or its analogs, minerals, and metabolites) protects cell from oxidative damage.”
- Zinc in Infection and Inflammation (2017, background): “However, excessive production of ROS and the decreased rate of its neutralization and removal by antioxidant defense mechanisms lead to an imbalance between oxidants and antioxidants which results in oxidative stress [61].”
- Zinc Oxide and Silicone Nanoparticles to Improve the Resistance Mechanism and Annual Productivity of Salt-Stressed Mango Trees (2020, background): “[100] reported that Zn protects cells against oxidative stress, because it is a structural component of SOD.”