Gli and hedgehog in cancer: tumours, embryos and stem cells

By A. R. I. Altaba, P. Sánchez, N. Dahmane. Nature Reviews. Cancer, 2002

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Brain micro-ecologies: neural stem cell niches in the adult mammalian brain (2008, background): “During development, Shh acts as a morphogen, playing a crucial role in ventral patterning along the entire extent of the neuraxis, and as a mitogen, stimulating granule cell precursor proliferation in the cerebellum (reviewed in Ruiz i Altaba et al. 2002).”
Mechanisms of stem cell self-renewal. (2009, background): “Hedgehog signaling is required not only for normal neural stem cell maintenance, but also for brain tumor cell proliferation (Balordi & Fishell 2007, Ruiz i Altaba et al. 2002).”
Cancer stem cells in nervous system tumors (2004, background): “…that dysregulate the pathways that control normal stem cell self-renewal (such as the sonic hedgehog pathway) cause brain tumors, emphasizing the mechanistic similarities between normal stem cell and cancer cell self-renewal (Dahmane et al., 2001; Ruiz i Altaba et al., 2002; Pardal et al., 2003).”
A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function (2008, background): “Many of the genes are astrocyte-enriched, although only three (Rfx4, Pbxip1, and Gli3) meet our criteria for being astrocyte-specific (at least 20-fold astrocyte-enriched).”