Genetic associations in large versus small studies: an empirical assessment.

By John P. A. Ioannidis, Thomas A. Trikalinos, E. Ntzani, D. Contopoulos-Ioannidis. The Lancet, 2003

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The future of association studies: gene-based analysis and replication. (2004, result): “Similar surveys of the association literature have been conducted, yielding successful replication rates of 16%‐30% (Ioannidis 2003; Ioannidis et al. 2003; Lohmueller et al. 2003).”
Candidate gene studies of ADHD: a meta-analytic review (2009, background): “Given these challenges, candidate gene studies require large samples to achieve adequate statistical power and replicable results (Ioannidis et al. 2003).”
Statistical strategies for avoiding false discoveries in metabolomics and related experiments (2007, background): “One of the chief causes of FDRs, however, is inadequate sample size (Ioannidis et al., 2001, 2003; Ransohoff, 2004; Wacholder et al., 2004; Ioannidis, 2005a, b; Ioannidis and Trikalinos, 2005; Ein-Dor et al., 2006; Todd, 2006), a feature that is particularly problematic in cases when the number of…”