γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2
By W. Kimberly, M. LaVoie, B. Ostaszewski, Wenjuan Ye, M. Wolfe, D. Selkoe. Proceedings of the National Academy of Sciences of the United States of America, 2003
812 citations recorded by the source corpus.
Subfields: Cell Biology, Nutrition and Dietetics, Physiology
View Paper: https://www.semanticscholar.org/paper/1c65c9103243c7f7b95d4784ecaa9d15cfb5215d
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Citations in the corpus
- Genetics of Alzheimer Disease (2010, positive): “This complex cleaves many type-I transmembrane proteins, including APP and Notch,(94,111) 2 proteins in the hydrophobic environment of the phospholipid bilayer of the membrane.(109) PSEN1 knockout (KO) mice are not viable,(112) but a conditional PSEN1 KO mouse model, where the loss of the gene is li”
- Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases (2004, background): “, and γ-secretase, an unusual intramembrane aspartyl protease containing presenilin at its catalytic site complexed with three other membrane proteins, nicastrin, Aph-1 and Pen-2 (ref”
- Functional γ-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and γ-secretase substrates (2003, neutral): “Chinese hamster ovary cells (designated as 30 cells; Kimberly et al., 2003) overexpressing wild-type (WT) human APP, WT human PS1, human 2 isoform of Aph1 with an HA tag fused at the C-terminus (Aph1 2-HA), and human Pen-2 with a Flag tag fused at the N-terminus (FlagPen-2) were maintained in 200 g/”
- APP processing in Alzheimer's disease (2011, background): “The PS1 NTF/CTF heterodimers are bound by transition-state analogue g-secretase inhibitors [102,106], sug-”
- Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease (2007, background): “Brain Aβ levels are regulated by a balance between enzymes that generate Aβ by promoting APP processing, such as β-secretase and the γ-secretase comple”
- Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “All four components are necessary for γ -secretase to mature and function correctly [19,20]. γ -Secretase has a relatively novel mechanism in that it cleaves within the lipid bilayer and can only process substrates that are first cleaved by another protease to remove a large ectodomain region [21].”