Oncogenic roles of EMT-inducing transcription factors

By A. Puisieux, Thomas Brabletz, J. Caramel. Nature Cell Biology, 2014

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Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, positive): “Notably, EMT is orchestrated by transcription factors (EMT-TFs), comprising SNAIL, ZEB and TWIST family, that regulate the expression of epithelial and mesenchymal genes 180 .”
Regulation of epithelial-mesenchymal transition through epigenetic and post-translational modifications (2016, background): “Transcription factors such as SNAIL, SLUG, ZEB1, and ZEB2/SIP1 are considered direct repressors of E-cadherin as they bind to E-boxes present on the CDH1 promoter [10, 33, 34].”
Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatment (2018, background): “It has been indicated that epithelial mesenchymal transition (EMT) markers and stem cell markers are coexpressed in circulating tumor cells from patients with metastasis [58] and EMT induction or activation of EMT transcription factors (TFs) confers stem-like features in cancer cells [59].”
Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “…eventually displaying gain of ZEB1 and VIM , but repressed CDH1 , MIR200C and MIR205 expression, was observed in vitro after long-term exposures to gemcitabine in BxPC3 pancreatic cancer cells and to Docetaxel in PC3 and DU-145 prostate cancer cells (Wellner et al , 2009; Puhr et al , 2012).”