Physical activity and colon cancer prevention: a meta-analysis
By K. Wolin, Yan Yan, Graham A Colditz, I. Lee. British Journal of Cancer, 2009
624 citations recorded by the source corpus.
Although an inverse association between physical activity and risk of colon cancer is well established, a formal estimate of the magnitude of this risk reduction that includes recent studies is not available. This analysis examines the association by sex and study design, restricting analyses to studies where data for colon cancer alone were available. The authors reviewed published studies through June 2008 examining the association between physical activity and risk of colon cancer. Heterogeneity and publication bias were evaluated and random effects models used to estimate relative risks (RR). Differences by sex and study design were evaluated. A total of 52 studies were included. An inverse association between physical activity and colon cancer was found with an overall relative risk (RR) of 0.76 (95% confidence interval (CI): 0.72, 0.81). For men, the RR was 0.76 (95% CI: 0.71, 0.82); for women, this was little different, (RR=0.79, 95% CI: 0.71, 0.88). The findings from case–control studies were stronger (RR=0.69, 95% CI: 0.65, 0.74) than for cohort studies (RR=0.83, 95% CI: 0.78, 0.88). This study confirms previous studies reporting an inverse association between physical activity and colon cancer in both men and women, and provides quantitative estimates of the inverse association.
Subfields: Oncology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/1c0c072e1ff124c2f75f97be365da50fec6dc1b2
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Citations in the corpus
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- Exercise Alters Gut Microbiota Composition and Function in Lean and Obese Humans (2017, background): “Physical activity has been shown to reduce risk of colorectal cancer and irritable bowel disease (38).”
- Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases (2015, background): “There is growing epidemiological evidence that a physically active lifestyle protects against the development of colon cancer, breast cancer, endometrial cancer, and prostate cancer (Thune and Furberg, 2001; Samad et al., 2005; Harriss et al., 2009; Wolin et al., 2009; Eliassen et al., 2010; Schmitz”
- Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies (2022, background): “A meta-analysis of 52 studies found that physical exercise frequency and intensity are inversely related to CRC risk [53].”
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