Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system.
By Thomas J. Carroll, Joo-Seop Park, S. Hayashi, A. Majumdar, Andrew P. McMahon. Developmental Cell, 2005
887 citations recorded by the source corpus.
The vertebrate urogenital system forms due to inductive interactions between the Wolffian duct, its derivative the ureteric bud, and their adjacent mesenchymes. These establish epithelial primordia within the mesonephric (embryonic) and metanephric (adult) kidneys and the Müllerian duct, the anlage of much of the female reproductive tract. We show that Wnt9b is expressed in the inductive epithelia and is essential for the development of mesonephric and metanephric tubules and caudal extension of the Müllerian duct. Wnt9b is required for the earliest inductive response in metanephric mesenchyme. Further, Wnt9b-expressing cells can functionally substitute for the ureteric bud in these interactions. Wnt9b acts upstream of another Wnt, Wnt4, in this process, and our data implicate canonical Wnt signaling as one of the major pathways in the organization of the mammalian urogenital system. Together these findings suggest that Wnt9b is a common organizing signal regulating diverse components of the mammalian urogenital system.
Subfields: Molecular Biology, Surgery, Urology
View Paper: https://www.semanticscholar.org/paper/1baa36f1a81f53561fc304496762c6c4fec64f37
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Citations in the corpus
- Epithelial Plasticity: A Common Theme in Embryonic and Cancer Cells (2013, background): “Eph and Ephrin signaling is also involved in the epithelialization of somites (39), andWnt signaling is required for MET during nephron development (40).”
- Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development (2008, methodology): “Six2+/ ; Wnt9b+/ mice were maintained on a 129/Sv 3 C57BL/6J 3 NMRI mixed background and intercrossed to obtain Six2 ; Wnt9b compound null mutants (Carroll et al., 2005; Self et al., 2006).”
- Patterning a complex organ: branching morphogenesis and nephron segmentation in kidney development (2010, positive): “As noted above, after the Six2-expressing MM cells extinguish Cited1, they begin to stabilize b-catenin in response to Wnt9b, which can instruct MM cells to undergo MET.”