Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism

By E. Dessaud, L. Yang, K. Hill, B. Cox, Fausto Ulloa, A. Ribeiro, A. Mynett, Bennett G. Novitch, James Briscoe. Nature, 2007

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How researchers see this paper

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Hedgehog Signaling in Development and Cancer (2008, neutral): “Interestingly, there is evidence that Gli3 R can block Wnt signaling by binding b -catenin and inhibiting its transcriptional activator activity (Ulloa et al., 2007).”
Morphogen gradients: from generation to interpretation. (2011, background): “…factors: (a) the concentration of Shh, (b) the length of exposure to Shh, (c) feedback loops between the pathway and target genes, and (d ) complex cross-regulatory interactions between target genes (Chamberlain et al. 2008; Dessaud et al. 2007, 2008, 2010; Lek et al. 2010; Ribes & Briscoe 2009).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “Both the concentration and timing of SHH exposure is important for establishing cell fat”
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network (2008, background): “The order in which class I genes are repressed is inversely related to their sensitivity to Shh signaling (Dessaud et al., 2007; Ericson et al., 1997).”
Partial differential equations for self-organization in cellular and developmental biology (2008, background): “Dessaud and co-workers [46] show that some form of temporal averaging is at work during chick limb specification; they show that changing the time and level of exposure to Shh have equivalent effects on intracellular signalling.”