Leptin in the regulation of immunity, inflammation, and hematopoiesis
By G. Fantuzzi, R. Faggioni. Journal of Leukocyte Biology, 2000
1,024 citations recorded by the source corpus.
Leptin, the product of the ob gene, is a pleiotropic molecule that regulates food intake as well as metabolic and endocrine functions. Leptin also plays a regulatory role in immunity, inflammation, and hematopoiesis. Alterations in immune and inflammatory responses are present in leptin‐ or leptin‐receptor‐deficient animals, as well as during starvation and malnutrition, two conditions characterized by low levels of circulating leptin. Both leptin and its receptor share structural and functional similarities with the interleukin‐6 family of cytokines. Leptin exerts proliferative and anti‐apoptotic activities in a variety of cell types, including T lymphocytes, leukemia cells, and hematopoietic progenitors. Leptin also affects cytokine production, the activation of monocytes/macrophages, wound healing, angiogenesis, and hematopoiesis. Moreover, leptin production is acutely increased during infection and inflammation. This review focuses on the role of leptin in the modulation of the innate immune response, inflammation, and hematopoiesis.
Subfields: Endocrine and Autonomic Systems, Epidemiology, Nutrition and Dietetics
View Paper: https://www.semanticscholar.org/paper/1afad2623d7e1ebfb1012e068578914d5aa67521
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Citations in the corpus
- Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, positive): “Moreover, although leptin was first described for its role in modulating food intake and energy expenditure, there is now substantial evidence that leptin is also involved in immune function (63), as evidenced by its effect to enhance cytokine production and phagocytosis by macrophages (130).”
- Endothelial dysfunction in diabetes mellitus (2007, neutral): “The role of tumor necrosis factor TNF- in vascular infl ammation is well known, and a role for leptin is emerging (Fantuzzi and Faggioni 2000; Plutzky 2001).”
- Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. (2018, neutral): “and then evolved to acquire overlapping but partly distinct roles (Fantuzzi and Faggioni, 2000; Zhang et al., 2005).”
- Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research (2006, background): “Leptin-deficient ob/ob mice exist in a state of perceived starvation (Fantuzzi & Faggioni 2000).”