Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

By R. Sekido, R. Lovell-Badge. Nature, 2008

725 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/1af69688ccd66a56ac8a1409a9246e3d7dd89970

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. M. Matzuk

In Molecular Biology

1. M. Matzuk

In Reproductive Medicine

1. Ankur K. Nagaraja
2. M. Matzuk
3. M. Edson

Citations in the corpus

• The mammalian ovary from genesis to revelation. (2009, background): “Furthermore, the initial low level of expression of Sox9 in the bipotential gonad requires SF1 (59), and the subsequent high level induction of Sox9 that is required for testis formation is regulated first by both SRY and SF1 and then by SF1 and SOX9 as part of a feedback loop (78).”
• Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. (2009, neutral): “…of the gonadal sexual phenotype in vertebrates and supports the model in which the decisive issue that determines the outcome of mammalian sex development and maintenance is whether SOX9 can establish an auto-regulatory self-maintaining loop or not (Kim et al., 2006; Sekido and Lovell-Badge, 2008).”