Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease.

By B. Brown, X. Zhao, A. Chait, L. Fisher, M. Cheung, Josh S. Morse, A. Dowdy, Emily K. Marino, E. Bolson, P. Alaupovic and 7 more. New England Journal of Medicine, 2001

1,850 citations recorded by the source corpus.

Subfields: Biochemistry, Geriatrics and Gerontology, Surgery

View Paper: https://www.semanticscholar.org/paper/1ad7f524ad5692f8a6823cd3b2c26b514fed5276

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. J. Chapman
2. A. Kontush
3. Peter Libby
4. J. Keaney
5. T. Vogt

In Surgery

1. Peter Libby
2. J. Keaney
3. E. Tuzcu
4. R. Stocker
5. Paul-Henry Schoenhagen
6. S. Grundy
7. T. Crowe
8. J. F. Stevens

Citations in the corpus

• Major Lipids, Apolipoproteins, and Risk of Vascular Disease (2009, neutral): “42) with a combination of 15 mg/dL higher HDL-C and 80 mg/dL lower non–HDL-C, alterations that are attainable with available lipidlowering agents.(19,20) The HR was not materially changed by addition of information on triglyceride.”
• Extended-release niacin or ezetimibe and carotid intima-media thickness. (2009, neutral): “Hypertension — no. (%) 96 (86) 82 (85) 0.69 Tobacco use — no. (%) 5 (5) 6 ( 6 ) 0.86”
• Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. (2004, background): “Several clinical trials support the efficacy of nicotinic acid for reduction of CHD risk, both when used alone (18,19) and in combination with statins (20,21).”
• The role of oxidative stress in atherosclerosis. (2009, methodology): “Among them was the CARET study, in which b-carotene (30 mg/d) was administered and was terminated early because of the increase in fatality due to cardiovascular events,(49) as well as the HPS(50) (Heart Protection Study) and HATS.(51) The studies are summarized in Table 3.”
• Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. (2003, methodology): “Trials using angiography and carotid ultrasound to measure atherosclerosis progression typically treated patients for 2 to 3 years.(12,14-16) The rapid regression observed in our study provides evidence of a more dynamic process.”
• Peanuts and Their Nutritional Aspects—A Review (2012, background): “Another important vitamin which is supplemented in the body by the intake of peanuts is vitamin B3 [29] (known as Niacin or its corresponding amines, Niacinamide or Nicotinamide), to an extent of 13.”
• Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? (2003, background): “At this juncture, the general use of antioxidant mixtures may not prove useful and could even interfere with other therapies and, therefore, is not advised (104).”
• The metabolic syndrome. (2003, positive): “In the HDL-Atherosclerosis Treatment Study (HATS), a small group of patients with coronary artery disease and low baseline HDL-C levels achieved significant clinical and angiographic benefit from the combination of simvastatin and at least 2 g of niacin daily [75].”
• Major Lipids, Apolipoproteins, and Risk of Vascular Disease (2010, background): “42) with a combination of 15 mg/dL higher HDL-C and 80 mg/dL lower non–HDL-C, alterations that are attainable with available lipidlowering agents.(19,20) The HR was not materially changed by addition of information on triglyceride.”