Dynamic RNA Modifications in Gene Expression Regulation.

By I. A. Roundtree, M. Evans, T. Pan, Chuan He. Cell, 2017

2,937 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1ac697d3e6ccb8915493ecd5f53bfb228198e527

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In Molecular Biology

1. Chuan He
2. Hailing Shi
3. Jiangbo W
4. Jianjun Chen
5. Huilin Huang
6. Hengyou Weng
7. Chao Xu
8. Hongbin Sun

Citations in the corpus

• YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “Are there more proteins that recognize m(6)A directly? How should we go about discovering the reader proteins of many other RNA modifications, such as the N(1)methyladenosine (m(1)A) [65], 5-methylcytosine (m(5)C) [66], N6,20-O-dimethyladenosine (m(6)Am) [67], and pseudouridine (w) [68]? Could a bet”
• Where, when and how: context-dependent functions of RNA methylation writers, readers, and erasers (2019, background): “Building on the understanding of its widespread prevalence on mRNA, recent work has uncovered that m6A plays an important role in gene expression regulation (Roundtree et al., 2017a), animal development (Frye et al.”
• Functions of N6-methyladenosine and its role in cancer (2019, background): “M6A is installed co-transcriptionally through the methyltransferase complex (MTC) that consists of METTL3 catalytic subunit and other accessory subunits including METTL14, WTAP, VIRMA, RBM15, and ZC3H13 [37].”
• YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs (2017, background): “Introduction N(6)-methyladenosine, the most common internal modification of eukaryotic mRNA, is associated with the maturation, translation, and eventual decay of protein-coding transcripts (Roundtree et al., 2017; Tuck, 1992).”
• Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism (2018, background): “FUNCTIONS IN RNA METABOLISM Recent accumulative studies revealed that m(6)A methylation regulates almost every aspect of mRNA metabolism, from expression and pre-mRNA processing in the nucleus to translation and mRNA decay in the cytoplasm.(1,3,4,10,118) m(6)A has been reported to be associated with”
• RNA N6-methyladenosine modification in cancers: current status and perspectives (2018, background): “Of them, N(6)-methyladenosine (m(6)A) is the most abundant internal modification on eukaryotic mRNAs.(5,6) The identification of the fat mass and obesity-associated protein (FTO) as a genuine demethylase of m(6)A modification(7) indicated that m(6)A is a reversible and dynamic RNA modification, anal”
• Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms (2020, neutral): “► We found that the percentage of patients with COVID- 19 with GI symptoms was also higher than that in Wuhan.”
• RNA modifications detection by comparative Nanopore direct RNA sequencing (2019, neutral): “qRT-PCR primers: 7sk (22-73): Fwd 5′-GCGACATCTGTCACCC CATT-3′; Rev 5′-CAGCCAGATCAGCCGAATCA-3′.”
• Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia (2019, background): “RNA epitranscriptomics represents a recently identified layer of regulation of genetic information (He, 2010; Roundtree et al., 2017a).”