The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

By Guang Lei, Yilei Zhang, Pranavi Koppula, Xiaoguang Liu, Jie Zhang, Steven H. Lin, J. Ajani, Qin Xiao, Z. Liao, Hui Wang and 1 more. Cell Research, 2020

1,089 citations recorded by the source corpus.

Subfields: Cancer Research, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/1aa7846c77eb061a46afd81c83d5e1c71bade968

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. Lei
2. Qing-zhang Tuo

In Pulmonary and Respiratory Medicine

1. P. Lei
2. Furong Zeng
3. Yu Meng
4. Yihuang Liu
5. Guangtong Deng
6. Xiang Chen
7. Yuming Sun
8. Jiayuan Le

Citations in the corpus

• Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research (2022, background): “Mechanistically, radiation causes lipid peroxidation and ferroptotic cell death through three parallel mechanisms at least [198, 319, 320].”
• Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications. (2022, neutral): “Radiation can induce ferroptosis, and ferroptosis inducers can act as radiosensitizers (Lei et al., 2020; Ye et al., 2020) alone or in combination with immunotherapy (Lang et al.”
• Ferroptosis: mechanisms and links with diseases (2021, background): “Ionizing radiation also upregulates the expression of ACSL4 in human cancer cells.(55) Erastin treatment in HeLa and NCI-H1975 adenocarcinoma cell lines aggravates radiation-induced cell death.”
• The interaction between ferroptosis and lipid metabolism in cancer (2020, background): “ACSL4 ablation significantly abolishes IR-induced ferroptosis and promotes radioresistance.(90) In addition, inhibiting 12-LOX can modulate the radiosensitivity of human prostate cancer cells,(91) suggesting that the P53/12-LOX-mediated, ACSL4-independent ferroptosis pathway may be involved in the r”
• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “372 Thirdly, irradiated tumor cell-derived microparticles (RT-MPs) induce a bystander effect via inducing ferroptosis, which causes the generation of oxidative stress and DNA damage in neighboring unirradiated cells.”