Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

By M. Aarts, Yitao Liu, Lidong Liu, S. Besshoh, M. Arundine, J. W. Gurd, Yu-tian Wang, Michael W. Salter, M. Tymianski. Science, 2002

1,045 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1a6864c89f19d80b80886f9529126f613a8e2421

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Kevin Fox
2. M. Duchen
3. Shu Zhang
4. Y. Wang
5. Ann Marie Craig
6. T. Lai
7. Mark P. Mattson
8. R. Balaban

In Molecular Biology

1. M. Duchen
2. Ann Marie Craig
3. Mark P. Mattson
4. R. Balaban
5. B. Glancy

Citations in the corpus

• Excitotoxicity and stroke: identifying novel targets for neuroprotection. (2014, positive): “but not the GluN2A–PSD95–nNOS interaction in the rat forebrain (Aarts et al., 2002).”
• A key role for TRPM7 channels in anoxic neuronal death. (2003, methodology): “801 (10 M), CNQX (10 M), and nimodipine (2 M), antagonists of NMDA and AMPA/kainate glutamate reIntroduction ceptors and L-type Ca2 channels, respectively (Sattler et al., 1998, 1999; Aarts et al., 2002).”
• Mitochondria in health and disease: perspectives on a new mitochondrial biology. (2004, background): “(1999) showed that suppression of PSD-95 expression selectively reduced cell death and NO generation in response to NMDA, without altering the net Ca2þ influx, and they have even remarkably managed to reduce infarct size in intact animals by using cleverly targeted constructs to detach PSD-95 from t”
• Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. (2019, neutral): “Knowledge of how to drive GPX4 expression pharmacologically in the brain and other organs has clear therapeutic implications for hemorrhagic stroke, and possibly other CNS and non-CNS conditions associated with ferroptotic death (e.g., Parkinson’s disease and liver ischemia; Bellinger et al., 2011; ”
• PDZ Domain Proteins: Plug and Play! (2003, background): “In parallel, the design of PDZ domain inhibitors could produce novel pharmacological tools of therapeutic interest ( 32 , 107 ).”
• Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. (2010, neutral): “Interestingly, NR-mediated currents were not affected in D tau74 and tau (cid:1) / (cid:1) mice, which is in line with normal synaptic activity upon treat-ment with Tat-NR2B9c (Aarts et al., 2002).”
• NMDA Receptor Subunits Have Differential Roles in Mediating Excitotoxic Neuronal Death Both In Vitro and In Vivo (2007, methodology): “Neurological score and cerebral infarction were examined 24 h after the MCAo onset.”
• The role of nitric oxide in pre-synaptic plasticity and homeostasis (2013, methodology): “This view is given further support by Frontiers in Cellular Neuroscience www.frontiersin.org October 2013 | Volume 7 | Article 190 | 10 standard deviation for the example in (C) during the course of LTP (x = mean, SD = standard deviation).”