Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis.

By H. Imai, Masaki Matsuoka, T. Kumagai, Taro Sakamoto, Tomoko Koumura. Current Topics in Microbiology and Immunology, 2017

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Ferroptosis, necroptosis, and pyroptosis in anticancer immunity (2020, background): “Glutathione peroxidase 4 (GPX4), a selenoprotein harboring a selenocysteine (Sec) in its catalytic center, is required for an efficient reduction in peroxidized phospholipids [61, 62].”
Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity (2020, unknown): “Gpx4 is a unique gene that encodes cytosolic, mitochondrial, and nucleolar isoforms (14).”
Emerging mechanisms and disease relevance of ferroptosis (2020, background): “5 days post conception (dpc), conditional-Gpx4-mutant mice revealed that GPX4 loss not only induces ferroptosis, but also results in neurodegeneration [19], loss of antiviral immunity [61], infertility, and ischemia/reperfusion injury in kidney and liver [27,28,62,63].”