S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles.

By R. Donato. International Journal of Biochemistry and Cell Biology, 2001

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S100B in brain damage and neurodegeneration (2003, background): “This could represent a means to regulate specific steps in the signaling pathways in which the respective target protein is involved (Donato, 2001).”
Intracellular and extracellular roles of S100 proteins (2003, background): “S100B has long been implicated in memory processes (for review see Donato, 1999, 2001).”
Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. (2005, background): “S100/calgranulins may be expressed by a wide array of cell types; in the specific context of inflammation and RAGE, these species may be produced in polymorphonuclear leukocytes, dendritic cells (DC), MP, and lymphocytes (Zimmer et al., 1995; Schafer and Heinzmann, 1996; Donato, 2001).”