Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection.

By Sanyukta Rana, S. Yue, Daniela Stadel, M. Zöller. International Journal of Biochemistry and Cell Biology, 2012

620 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/19a91629e4a896774c7f762550b488098d1f7a3c

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In Immunology and Allergy

In Molecular Biology

Citations in the corpus

Exosomes in Tumor Microenvironment Influence Cancer Progression and Metastasis (2013, background): “Recent studies indicate that the tetraspanin–integrin complex contributes considerably in targeting enabling the binding of exosomes to target cells [27, 28].”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “In contrast, EVs derived from the highly metastatic rat pancreatic adenocarcinoma line BSp73ASML, which are enriched, in α6β4 and tetraspanins CD151 and Tspan8, preferentially target lung and lymph node stroma cells (114).”
Routes and mechanisms of extracellular vesicle uptake (2014, background): “It is possible that a population of EVs can simultaneously trigger a number of different gateways into a cell, with the primary entry points depending on the cell type and EV constituents (29,37,38).”
The exosome journey: from biogenesis to uptake and intracellular signalling (2021, positive): “Tetraspanins CD9, CD63, CD37, CD81, CD82, CD53 Exosome biogenesis, exosome cargo selection, targeting and uptake [107, 187]”
Shedding light on the cell biology of extracellular vesicles (2018, positive): “They have been shown to interact with integrins 144 and to promote exosome docking and uptake by selected recipient cells 145,146 .”
Exosomes in cancer development, metastasis, and immunity (2019, background): “Several reports have suggested that adhesion-associated molecules on the surface of exosomes, such as tetraspanins, glycoproteins, and integrins, determine which cells accept exosomes [49, 50].”
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research (2013, positive): “Immunologic techniques have the potential for high specificity (241,242), an important consideration in the characterization of unique EV populations.”
Exosomes as Drug Delivery Vehicles for Parkinson’s Disease Therapy (2015, background): “Furthermore, exosomal surface is rich with tetraspanins and integrins [24, 31, 89] that enable the efficient attachment to the plasma membrane of target cells.”
Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting (2015, background): “Others have shown that the tetraspanin-repertoire of EVs can influence the in vivo biodistribution and uptake in different cells (46,47).”
Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression (2018, background): “By contrast, EVs differing only in the expression of Tspan8 (released from the Tspan8-transfected non-metastatic variant BSp73AS-Tspan8 cell line), rather selectively target endothelial cells (133).”
Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes (2019, background): “Similarly, exosomal tetraspanin complexes are also involved in target cell selection in vitro and in vivo [23], possibly by modulating integrins [24].”
Engineering exosomes for targeted drug delivery (2021, background): “For example, CXCR4/SDF-1α interaction was shown to mediate the selective transfer of endothelial colony-forming cell (ECFC)-derived exosomes to the kidney, and most lymph node stroma-derived EVs containing TSPAN8–integrin alpha-4 complexes were found to be selectively taken up by endothelial cells o”
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. (2014, background): “EVs from a tumor cell line expressing the tetraspanin Tspan8 are enriched in α4 integrin and probably bind to ICAM1 on endothelial and pancreatic cells (Rana et al. 2012).”