A bioavailability score.

By Y. Martin. Journal of Medicinal Chemistry, 2005

905 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Lipophilicity in drug discovery (2010, background): “Martin has shown that different rules can perform better for different ionisation types to predict rat bioavailability for a series of 553 Abbott compounds [47].”
Combining docking and molecular dynamic simulations in drug design (2006, background): “21,22 Similarly, drug-likeness of potential leads may be less important at the early stages than ease of the molecule to experimental validation with in vitro assays and X-ray crystallography.”
Virtual ligand screening: strategies, perspectives and limitations (2006, background): “and Martin, E.J. (2004) Target-based scoring approaches and expert”
The influence of drug-like concepts on decision-making in medicinal chemistry (2007, background): “, and number of rule-of-five violations, PSA and ionization stat”
The influence of lipophilicity in drug discovery and design (2012, background): “However there have been studies that have failed to show a direct correlation between log P and bioavailability [69] and these studies suggest that other parameters like PSA, rotatable bonds, and ionization state are better predictors of bioavailability [5,12,69].”