Engineered gene circuits

By Jeff Hasty, David R. McMillen, James J. Collins. Nature, 2002

747 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/19267a5767e692957c29de48c1649ae51bbd6d2a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biophysics

In Molecular Biology

Citations in the corpus

Application of formal methods to biological regulatory networks: extending Thomas' asynchronous logical approach with temporal logic. (2004, methodology): “Computational systems biology (Wolkenhauer, 2001) tries to establish methods and techniques that enable us to understand biological systems as architectural systems, including their robustness, design and manipulation (Kitano, 2002a; Hasty et al., 2002).”
Formal molecular biology (2004, background): “Forward engineering of biological systems focuses on the analysis and construction of the basic components one can engineer in biological systems [14].”
A review of imaging techniques for systems biology (2008, background): “Implementing systems biology models in conjunction with imaging provides a way to refine understanding of biological systems [18].”
A methodology for the structural and functional analysis of signaling and regulatory networks (2006, background): “[67-69]) the logical description and analysis of large signaling networks has a strong relationship to electrical circuit analysis; however, there still seems to be a large potential in employing theoretical and software tools from electrical engineering and Boolean logic for investigating interacti”
A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches. (2009, positive): “Thanks to the emerging fields of systems and synthetic biology (Hasty et al., 2002; Hayete et al., 2007; Kaern et al., 2003; Sprinzak and Elowitz, 2005), scientists are beginning to unravel these regulatory, signaling, and metabolic interactions and to understand their coordinated action.”
Robustness of Cellular Functions (2004, neutral): “( Hasty et al., 2002).”
DIVERSITY-BASED, MODEL-GUIDED CONSTRUCTION OF SYNTHETIC GENE NETWORKS WITH PREDICTED FUNCTIONS (2009, background): “A major focus of the field is the synthesis of gene networks with predictable behavio”
Evolutionary conservation of motif constituents in the yeast protein interaction network (2003, background): “N(1) is the number of proteins directly interacting with protein i.”