Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.

By Yong-Sheng Chang, E. Tomaso, D. McDonald, Rosemary Jones, Rakesh K. Jain, Lance L. Munn. Proceedings of the National Academy of Sciences of the United States of America, 2000

706 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/1922796d01f1913974321371edeff4daaa3e23a6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biomedical Engineering

1. M. Egeblad
2. Erik Sahai
3. Rakesh K. Jain
4. Zena Werb
5. D. Lyden
6. E. Nakasone
7. Triantafyllos Stylianopoulos

In Cancer Research

1. Rakesh K. Jain
2. Peter Carmeliet
3. B. Larrivée
4. C. Viallard
5. K. Alitalo
6. Zena Werb
7. M. Egeblad
8. E. Nakasone

In Molecular Biology

1. Peter Carmeliet
2. Rakesh K. Jain
3. K. Alitalo
4. Zena Werb
5. B. Larrivée
6. C. Viallard
7. M. Egeblad
8. E. Nakasone

Citations in the corpus

• Tumors as organs: complex tissues that interface with the entire organism (2010, positive): “Although the degree to which cancer cells resemble endothelial cells is debatable, there is agreement that cancer cells can directly line the lumen of functional tumor blood vessels (Chang et al., 2000; McDonald et al., 2000).”
• Brain metastases: epidemiology and pathophysiology (2005, background): “Tumor blood vessels differ from normal vessels in the host organ in that the tumor-induced endothelial cells are less complete, allowing cancer cells to more easily enter the vessel lumen [62].”
• Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? (2002, background): “Similarly, mosaic blood vessels that are partially lined by tumour cells can support tumour vessel wall”
• Vascular endothelial growth factor (VEGF) signaling in tumor progression. (2007, background): “Chang and co-workers found that about 15% of vessels in human colon carcinoma implants (xenografts) in athymic hairless, or nude, mice and in biopsies of human colon carcinomas were mosaic channels lined with both endothelial and tumor cells [22].”
• Illuminating the metastatic process (2007, background): “In situ imaging has unambiguously demonstrated that GFP-labelled tumour cells can form part of the lumen of blood vessel”
• Molecular mechanisms of lymphangiogenesis in health and disease. (2002, background): “These factors could also alter the tumor interstitial fluid pressure, which might determine tumor cell seeding, especially as recent studies revealed that a proportion of the lumen of tumor blood vessels themselves consists of tumor cells (Chang et al., 2000).”
• Tumor angiogenesis and vascular normalization: alternative therapeutic targets (2017, background): “Moreover, tumor cells can be integrated in the walls of tumor-associated blood vessels, forming so-called mosaic vessels [64].”
• Molecular regulation of vessel maturation (2003, background): “Some ECs do not express common endothelial markers (such as CD31) and may undergo apoptosis, thus exposing cancer cells to the lumen (so-called mosaic vessels”