Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide.

By M. Krampera, S. Glennie, J. Dyson, D. Scott, R. Laylor, E. Simpson, F. Dazzi. Blood, 2003

1,632 citations recorded by the source corpus.

Subfields: Genetics, Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/191fc2e2d4d180cef672a126d695fe56df5b2412

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In Genetics

1. A. Caplan
2. W. Fibbe
3. O. Ringdén
4. Frank Barry
5. L. Meirelles
6. D. Prockop

In Hematology

1. A. Caplan
2. W. Fibbe
3. O. Ringdén

In Immunology

1. W. Fibbe

Citations in the corpus

• Mesenchymal stem cells and immunomodulation: current status and future prospects (2016, background): “Krampera et al.50 reported that the inhibitory effect of MSCs on T cells requires the presence of MSCs in culture and MSC–T-cell contact.”
• Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis (2010, background): “Recent studies have described the following additional properties of MSCs: (1) a debatable ability to transdifferentiate into cells of endodermal and ectodermal origin,(6,47,48) including possible neural transdifferentiation,(15,17,19) and (2) systemic (peripheral) and local (in the CNS) immunomodul”
• Mesenchymal Stem Cells for Treatment of Therapy-Resistant Graft-versus-Host Disease (2006, background): “Patient 7 received HLA-mismatched MSC on day 81 and MSC from his mother on day 96.”
• Mesenchymal stem cells: clinical applications and biological characterization. (2004, background): “Krampera et al. also suggest that MSCs inhibited both naive and memory T-cell responses and may function to physically hinder T-cell contact with antigen presenting cells in a noncognate fashion ( Krampera et al., 2003 ).”
• Mechanisms involved in the therapeutic properties of mesenchymal stem cells. (2009, background): “The realization that cultured MSCs have immunomodulatory properties comes from experiments where they were shown to directly inhibit the proliferation of ab T cells in vitro [57,58].”