Scoring functions for cryoEM density fitting.

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Assessment of three-dimensional RNA structure prediction in CASP15 (2023, neutral): “70,71 We note that no metrics tested were RNA specific and can be used to assess any macromolecular complex.”
Recent developments in the CCP-EM software suite (2017, methodology): “TEMPy TEMPy implements a wide variety of scoring functions for model-to-map and map-to-map fits (Vasishtan & Topf, 2011; Farabella et al., 2015; Joseph et al., 2017), as well as other functions for map and model manipulations.”
Integrating model simulation tools and cryo‐electron microscopy (2022, unknown): “127,174,203 CC evaluates model fit by assessing the similarity between two pixelated volumes.”
Improved metrics for comparing structures of macromolecular assemblies determined by 3D electron-microscopy (2017, methodology): “The Normal Vector score was calculated as the average angle between the normal vectors at aligned surface points (Ceulemans and Russell, 2004; Vasishtan and Topf, 2011), normalized as:”