Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents.

By Rama Adikrisna, Shinji Tanaka, Shunsuke Muramatsu, Arihiro Aihara, D. Ban, T. Ochiai, T. Irie, A. Kudo, N. Nakamura, S. Yamaoka and 1 more. Gastroenterology, 2012

1,026 citations recorded by the source corpus.

Subfields: Biotechnology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/18fb0dd9773bf23bb38ee07efb1fb97937d67858

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Citations in the corpus

Evolution of the cancer stem cell model. (2014, background): “…identifying CSCs in numerous cancers including brain (Singh et al., 2004), head and neck (Prince et al., 2007), pancreas (Hermann et al., 2007; Li et al., 2007), lung (Eramo et al., 2008), prostate (Collins et al., 2005; Patrawala et al., 2006), colon (O’Brien et al., 2007; Ricci-Vitiani et…”
Oxidative stress, inflammation, and cancer: how are they linked? (2010, background): “The first conclusive evidence for CSCs was published in 1997 [286], and to date CSCs have been isolated from both leukemias and a variety of solid tumors, including breast, brain, pancreatic, prostrate, ovary, and colon cancers [287-293].”
Mechanisms of chemoresistance in cancer stem cells (2013, background): “This includes the identification of solid tumor CSCs in a variety of organs including liver, brain, colon, pancreas, lung, ovaries and prostate [9-11,14-17].”
Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis (2015, background): “Notch signaling can induce EMT and maintain stemness (170); however, our understanding of the different roles of the two sub-families of ligands (Delta and Jagged) of Notch signaling is only recent (171–173), and incomplete in the context of EMT and/or CSCs. Notwithstanding this lack of knowledge, J”
EMT and dissemination precede pancreatic tumor formation (2012, background): “In human pancreatic tumors, this activity may be contained within a CD24+CD44+ population of cells, among others (Hermann et al., 2007; Jimeno et al., 2009; Li et al., 2007).”
Transient Low Doses of DNA Demethylating Agents Exert Durable Anti-tumor Effects on Hematological and Epithelial Tumor Cells (2012, background): “The ultimate test of tumor initiation for leukemia and solid tumor cells (Lapidot et al., 1994; Al-Hajj et al., 2003; Li et al., 2007; O’Brien et al., 2007; Ricci-Vitiani et al., 2007; Schatton et al., 2008; Singh et al., 2004) is engraftment capability and tumor growth of the most tumorigenic or…”
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer. (2010, neutral): “Similar findings have been reported for cancers of the breast, brain, colon, ovary, pancreas, and prostate (Al-Hajj et al., 2003; Li et al., 2007; O’Brien et al., 2007; Singh et al., 2003; Zhang et al., 2008b).”
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. (2011, positive): “For example, subpopulations of stem-like cancer cells with increased tumor-seeding ability and drug resistance have been identified in a variety of tumor types (Al-Hajj et al., 2003; Lapidot et al., 1994; Li et al., 2007; Singh et al., 2004; Smalley and Ashworth, 2003; Stingl and Caldas, 2007).”