Krüppel-like Factors: Three Fingers in Many Pies*

By J. Bieker. Journal of Biological Chemistry, 2001

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KLF2 Is a Novel Transcriptional Regulator of Endothelial Proinflammatory Activation (2004, background): “Kruppel-like factors (KLFs) are a subclass of the zinc finger family of transcription factors which regulates cellular differentiation and tissue development (20).”
Long‐range chromosomal interactions regulate the timing of the transition between poised and active gene expression (2007, background): “In this context, it was interesting that we have shown that Sp/X-KLF factors, known to behave as activators in erythroid cells (Bieker, 2001; Van Loo et al, 2003), bind to the promoter only when the genes are activated and could provide part of the final trigger for globin expression.”
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. (2002, background): “In vitro studies have suggested a role for Klf4 in cell proliferation and/or differentiation (Bieker, 2001).”
The human β‐globin locus control region (2002, background): “The CACCC element is bound by members of the family of krüppel-like zinc finger (KLF) proteins [16].”