Emergence of Oxacillinase-Mediated Resistance to Imipenem in Klebsiella pneumoniae

By L. Poirel, C. Héritier, V. Tolün, P. Nordmann. Antimicrobial Agents and Chemotherapy, 2004

1,038 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Pollution

View Paper: https://www.semanticscholar.org/paper/185179926d7ef61e639e9cd7d5ce040e057de595

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. L. Poirel
2. P. Nordmann
3. K. Bush
4. A. Queenan
5. T. Naas
6. L. Logan
7. Robert A. Weinstein
8. Young Bae Kim

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. K. Bush
4. P. Bradford
5. Robert A. Weinstein
6. L. Logan
7. T. Naas
8. A. Carattoli

In Pollution

1. P. Nordmann
2. L. Poirel
3. K. Bush
4. Young Bae Kim
5. Jung Hun Lee
6. Chang-Ro Lee
7. B. Jeong
8. S. Lee

Citations in the corpus

• Epidemiology of β-Lactamase-Producing Pathogens (2020, background): “penicillins and imipenem and lower hydrolysis of meropenem (239).”
• The Epidemiology of Carbapenem-Resistant Enterobacteriaceae: The Impact and Evolution of a Global Menace (2017, background): “pneumoniae, and since then OXA-producing bacteria have become endemic in that country [57].”
• Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance (2017, background): “Although other carbapenemase genes occured in K. pneumoniae and were even reported in this species for the first time, such as blaOXA-48 (Poirel et al. 2004) and blaNDM-1 (Yong et al. 2009), it is undoubtable that blaKPC became the most prevalent and highly impacting carbapenemase in K. pneumoniae.”
• Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods (2016, background): “The OXA-48 was first identified in K. pneumoniae in Turkey in 2003 (Poirel et al., 2004), and thus far, 10 variants of the blaOXA−48 gene have been identified (Jeon et al., 2015).”
• Carbapenemases: the Versatile β-Lactamases (2007, background): “At the latest count, there are nine major subgroups of OXA carbapenemases, based on amino acid homologies, as summarized in Table 6 (18, 167, 225).”
• Global Spread of Carbapenemase-producing Enterobacteriaceae (2011, background): “pneumoniae strain isolated in Turkey in 2003 (21).”
• The global epidemiology of carbapenemase-producing Enterobacteriaceae (2017, background): “was a Klebsiella pneumoniae strain that was isolated in Turkey in 2001.(72) OXA-48-like producing Klebsiella pneu-”
• OXA β-Lactamases (2014, background): “Analysis of the enzyme kinetics of OXA-48 showed that the enzyme has a low level of hydrolytic activity against the carbapenems, with much greater activity against imipenem than against meropenem (Table 2) (62).”
• Rapid evolution and spread of carbapenemases among Enterobacteriaceae in Europe. (2012, background): “aeruginosa, only anecdotal reports of currently important carbapenemases such as KPCs belonging to class A [6] or OXA-48 belonging to class D [7] had been published, and NDM-1 belonging to class B had not been described [8].”
• The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. (2014, background): “Then, OXA-48 producers have been extensively reported from Turkey, being often the sources of nosocomial outbreaks [96-99].”
• Colonization, Infection, and the Accessory Genome of Klebsiella pneumoniae (2018, background): “The plasmid encoded OXA-48 (blaOXA-48) is found in K. pneumoniae and confers a high level of resistance to imipenem (Poirel et al., 2004).”