The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats

By F. Bareyre, M. Kerschensteiner, O. Raineteau, T. Mettenleiter, O. Weinmann, Martin E. Schwab. Nature Neuroscience, 2004

1,092 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/183ccf54156584b1a65bbbbdbbd5a3702e4f1ae8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. J. Frisén
2. Zhigang He
3. Roger N. Lemon

Citations in the corpus

• PTEN Deletion Enhances the Regenerative Ability of Adult Corticospinal Neurons (2010, background): “Results Correlation between mTOR levels and CST sprouting We first investigated whether mTOR activity regulates the sprouting responses of CST axons after unilateral pyramidotom”
• Application of reinforcement learning for segmentation of transrectal ultrasound images (2008, neutral): “Because, many different types of movements are controlled through the fibers of the CST, understanding how this tract adapts to SCI is the focus of current experimental efforts [2,3].”
• Altering spinal cord excitability enables voluntary movements after chronic complete paralysis in humans. (2014, background): “Exercise training after spinal cord injury in a rodent model has been shown to enhance corticospinal tract sprouting and increased functional connections to spinal neurons (Bareyre et al., 2004; Engesser-Cesar et al., 2007; Courtine et al., 2008; Goldshmit et al., 2008; Flynn et al., 2013).”
• Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome (2005, background): “The formation of new intraspinal circuits relaying cortical input from the injured, sprouting corticospinal tract above the injury to centers below injury through other remaining descending pathways has been brought forward as an explanation for spontaneous functional recovery after spinal cord inju”
• Reactive gliosis and the multicellular response to CNS damage and disease (2014, neutral): “for formation of new relay circuits (Bareyre et al., 2004; Carmichael, 2006; Clarkson et al., 2010; Courtine et al., 2008; Li et al., 2010; Overman et al., 2012).”
• Descending pathways in motor control. (2008, background): “There are fast, activity-dependent, plastic changes that occur soon after a lesion is placed in a descending pathway (Steward et al. 2003, Bareyre et al. 2004, Deumens et al. 2005, Vavrek et al. 2006).”