The prognostic role of a gene signature from tumorigenic breast-cancer cells.

By Rui Liu, Xinhao Wang, Grace Y. Chen, Piero Dalerba, A. Gurney, T. Hoey, Gavin Sherlock, J. Lewicki, Kerby Shedden, M. Clarke. New England Journal of Medicine, 2007

1,055 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology

View Paper: https://www.semanticscholar.org/paper/17ffeb3e0b6229232c6895a2804bd3214868bbc3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Weinberg
2. Howard Y. Chang
3. A. Mantovani
4. K. Polyak
5. Aviv Regev
6. A. Lluch
7. Eran Segal
8. A. Sica

In Oncology

1. R. Weinberg
2. A. Mantovani
3. A. Sica
4. P. Allavena
5. C. Garlanda
6. Jeffrey M. Rosen
7. F. Colotta
8. T. Vargo-Gogola

Citations in the corpus

• Down-regulation of miRNA-200c Links Breast Cancer Stem Cells with Normal Stem Cells (2009, background): “Indeed, a gene signature established from BCSCs was strongly associated with patient prognosis (Liu et al., 2007).”
• Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. (2009, background): “which have been proposed to represent breast cancer stem cell-like markers (46).”
• Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition (2008, background): “several components of the Ras/MAPK pathway are present in the expression profile of CD24(2) cancer cells [28], this observation suggested that cancer stem cells could be generated in response to”
• Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients (2009, result): “This assumption is supported by the observation that primary tumor stem cells show an expression profile associated with metastatic relapse in breast cancer patients [27].”
• Identification of selective inhibitors of cancer stem cells by high-throughput screening (2009, methodology): “A previous report has suggested that this signature is correlated inversely with both metastasis-free survival and overall survival for four different types of tumors (Liu et al., 2007).”
• Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “This dual function of inflammatory cells and mediators is reflected by studies on correlations between parameters of CRI and clinical behaviour in different contexts [182-187].”