Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017alpha and P450 aromatase localized in neurons.
By Y. Hojo, T. Hattori, T. Enami, A. Furukawa, Kumiko Suzuki, H. Ishii, H. Mukai, John H. Morrison, W. Janssen, S. Kominami and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2004
692 citations recorded by the source corpus.
Subfields: Behavioral Neuroscience, Endocrinology, Diabetes and Metabolism, Genetics
View Paper: https://www.semanticscholar.org/paper/17fba08b013fff0a9e24db6e962c58d64fa82563
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Citations in the corpus
- Studying sex and gender differences in pain and analgesia: a consensus report. (2007, neutral): “, progesterone [136,184], estradiol [9,86,108]).”
- Neurobiological and Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) and DHEA Sulfate (DHEAS) (2008, background): “Rat brains were capable of converting pregnenolone into DHEA and this may be activity-dependent [127].”
- Evolving knowledge of sex differences in brain structure, function, and chemistry. (2007, background): “strogen synthesis (32) and estrogen receptor messenger RNA mRNA) have been localized to the hippocampus (33,34), hereas androgen receptors are more prevalent in the amygdala 35) (see 36 for further discussion on estrogen receptor distribuion and the relationship to psychiatry).”
- Estrogen Actions in the Brain and the Basis for Differential Action in Men and Women: A Case for Sex-Specific Medicines (2010, background): “For example, transfection studies indicate that tamoxifen is an antagonist of ER-mediated transcriptional activation when this occurs via ERE-dependent mechanisms, but when ER interacts with the activated protein-1 pathway, tamoxifen is an effective agonist (Kushner et al., 2000).”