The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease
By N. El-Sayed, P. Myler, D. Bartholomeu, D. Nilsson, Gautam Aggarwal, A. Tran, E. Ghedin, Elizabeth A. Worthey, Arthur L. Delcher, G. Blandin and 72 more. Science, 2005
1,399 citations recorded by the source corpus.
Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 represent allelic pairs. Over 50% of the genome consists of repeated sequences, such as retrotransposons and genes for large families of surface molecules, which include trans-sialidases, mucins, gp63s, and a large novel family (>1300 copies) of mucin-associated surface protein (MASP) genes. Analyses of the T. cruzi, T. brucei, and Leishmania major (Tritryp) genomes imply differences from other eukaryotes in DNA repair and initiation of replication and reflect their unusual mitochondrial DNA. Although the Tritryp lack several classes of signaling molecules, their kinomes contain a large and diverse set of protein kinases and phosphatases; their size and diversity imply previously unknown interactions and regulatory processes, which may be targets for intervention.
Subfields: Epidemiology, Molecular Biology, Public Health, Environmental and Occupational Health
View Paper: https://www.semanticscholar.org/paper/17e61e2209e11eb12e9523c040b414192b19602d
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Citations in the corpus
- TriTrypDB: a functional genomic resource for the Trypanosomatidae (2009, background): “cruzi CL Brener, Esmeraldo and non-Esmeraldo-like haplotypes (41 chromosomes, 67Mb) (7,12); L.”
- The revised Trypanosoma cruzi subspecific nomenclature: rationale, epidemiological relevance and research applications. (2012, background): “The sequencing effort revealed that CL Brener genome contains 22,000 protein-encoding genes, and that over 50% is represented by repetitive sequences, consisting mostly of large gene families of surface proteins, retrotransposons, subtelomeric repeats (El-Sayed et al., 2005) and the T.”
- Comparative genomic analysis of three Leishmania species that cause diverse human disease (2007, background): “(the causative agent of African trypanosomiasis) and Trypanosoma cruzi”