Naturally occurring variations in maternal behavior in the rat are associated with differences in estrogen-inducible central oxytocin receptors

By F. Champagne, J. Diorio, Shakti Sharma, Michael Joseph Meaney. Proceedings of the National Academy of Sciences of the United States of America, 2001

665 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Experimental and Cognitive Psychology, Social Psychology

View Paper: https://www.semanticscholar.org/paper/17c8f5af16a25f6ec23a90472b1abacfa1f62afc

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Citations in the corpus

Adult attachment predicts maternal brain and oxytocin response to infant cues (2009, background): “…processing system (Champagne et al, 2004; Strathearn et al, 2008; Ferris et al, 2005) and 2) the oxytocinergic system (Bartels and Zeki, 2004; Champagne et al, 2001; Levine et al, 2007) Oxytocin, a neuromodulatory hormone produced in the hypothalamus, has well-described central actions…”
Oxytocin: the Great Facilitator of Life (2009, neutral): “, the BNST, mPOA, and lateral septum) and maternal aggression (i.e., the central nucleus of the amygdala; Champagne et al., 2001; Francis et al., 2000).”
A developmental, mentalization-based approach to the understanding and treatment of borderline personality disorder (2009, background): “, 2004; Strathearn, Li, Fonagy, & Montague, 2008) and (b) the oxytocinergic system (Bartels & Zeki, 2004; Champagne et al., 2001; Levine, Zagoory-Sharon, Feldman, & Weller, 2007).”
The social re-orientation of adolescence: a neuroscience perspective on the process and its relation to psychopathology (2005, background): “For example, circulating levels of estrogen can increase oxytocin receptor density within the amygdala, septum, nucleus accumbens, and bed nucleus of the stria terminalis of female rats, and the oxytocin receptor density in these regions may be related to the amount of nurturant behavior bestowed up”
Variations in maternal care in the rat as a mediating influence for the effects of environment on development. (2003, background): “Recent studies suggest that oxytocin receptor levels are functionally related to differences in licking/grooming [21,22].”
Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior. (2009, background): “Furthermore, infusion of an OTR antagonist reduces LG levels in high LG dams [26].”
25 Oxytocin and Vasopressin: Genetics and Behavioral Implications (2006, background): “Estrogen induced OTR in the LS, CeA, PVN, and BNST can affect grooming and licking behavior in rats, both of which are part of the normal repertoire of maternal behaviors (Champagne et al., 2001; Francis et al., 2002).”
The Neurobiology of Parental Behavior (2003, background): “Curiously, in this study, virgin female offspring of high- and low-licking and grooming dams differed in their response to estrogen (Champagne et al., 2001).”
Epigenetics and the biological definition of gene x environment interactions. (2010, background): “Estrogen acts during late gestation to increase oxytocin receptor levels in the MPOA (Fahrbach & Pfaff, 1986; Pedersen, 1997), and this effect is greater in the female offspring of highcompared to low-LG mothers (Champagne et al., 2001), reflecting the increased sensitivity to estrogen.”
Natural variations in maternal and paternal care are associated with systematic changes in oxytocin following parent-infant contact. (2010, background): “These findings provide a human parallel to the results obtained in animal models, which showed an increase in brain OT receptors only among the high LG-ABN dams (Francis et al., 2000).”