Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection.

By J. Ruiz. Journal of Antimicrobial Chemotherapy, 2003

745 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Evolutionary paths to antibiotic resistance under dynamically sustained drug stress (2011, background): “Evolution of resistance through the acquisition of single spontaneous mutations is particularly relevant for certain drugs, such as quinolones and rifamycin, for which high-level resistance can result from a single point mutatio”
Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. (2015, background): “resistance to rifampicin and fluoroquinolones is caused by mutations in the genes encoding the targets of these molecules, RpoB and DNA-topoisomerases, respectively) (Ruiz, 2003).”
Acquired Antibiotic Resistance Genes: An Overview (2011, background): “Single nucleotide polymorphisms (SNPs) can be the cause for resistance against the synthetic drugs quinolones, sulfonamides, and trimethoprim (Huovinen et al., 1995; Hooper, 2000; Ruiz, 2003) and mutations within the rpsL gene, which encodes the ribosomal protein S12, can result in a high-level stre”